df.rename(columns={'oldName1': 'newName1',
                   'oldName2': 'newName2'},
          inplace=True, errors='raise')
# Make sure you set inplace to True if you want the change
# to be applied to the dataframe

df = df.rename(columns={"old_col1": "new_col1", "old_col2": "new_col2"})

import pandas as pd
data = pd.read_csv(file)
data.rename(columns={'original':'new_name'}, inplace=True)

df.rename(columns={"old_col1": "new_col1", "old_col2": "new_col2"}, inplace=True)

df.columns = ['V', 'W', 'X', 'Y', 'Z']

df.rename({0: 'links'}, axis=1, inplace=True)