In [1]: import pandas as pd
df_1 = pd.DataFrame({"A":["foo", "foo", "foo", "bar"], "B":[0,1,1,1], "C":["A","A","B","A"]})
df_2 = pd.DataFrame({"A":["foo", "bar", "foo", "bar"], "B":[1,0,1,0], "C":["A","B","A","B"]})

In [2]: df = pd.concat([df_1, df_2])

In [3]: df
Out[3]: 
     A  B  C
0  foo  0  A
1  foo  1  A
2  foo  1  B
3  bar  1  A
0  foo  1  A
1  bar  0  B
2  foo  1  A
3  bar  0  B

In [4]: df.drop_duplicates(keep=False)
Out[4]: 
     A  B  C
0  foo  0  A
2  foo  1  B
3  bar  1  A