// Input field listens to change, updates React's state and re-renders the component.
<input onChange={e => this.setState({ value: e.target.value })} value={this.state.value} />

// Button is disabled when input state is empty.
<button disabled={!this.state.value} />

const buttonRef = useRef();

const disableButton = () =>{
  buttonRef.current.disabled = true; // this disables the button
 }

<button
className="btn btn-primary mt-2"
ref={buttonRef}
onClick={disableButton}
>
    Add
</button>